Attaining knowledge of nature and changes of sanctions, referred to by the great leader as a full economic war, is necessary for planning political and economic strategies against sanctions. Studying the way and structure of Obama`s sanctions, one understands that a different return has been formed in sanctions with regard to their form, economic part of the goal, the way of execution and intensity aiming at increasing pressure on Iranians to cause them to become unsatisfied and act against Iran`s Government. The main agent in the field for USA lies in the event of 1388 due to which the enemy hope to make IRI defeated from inside. Needless to say, along with the agent the increase of IRI area`s power and frequent defeats of Israel regime facing the resistant current, the changes in world oil market and defeat of purposed sanctions may be known as effectual in the field. Such being the case, opposing economic weaknesses, specially its being dependent on oil, should be centered on as the most effectual strategy to oppose the sanctions.