Lifestyle is one of the main concerns of thinkers in the field of social sciences and cultural field; However, due to the slowness of the lifestyle change process, political and security analysts see this category less as a strategic and security factor. Therefore, the present article deals with the relationship between the change of lifestyle and the change of political regime, in which the policies of the American government towards the Islamic Republic of Iran are emphasized. The main question of this research is: "What is the relationship between the change of lifestyle and the change of the political regime and how does the American government follow the change of the political system in Iran by affecting the life pattern of Iranians?" Surveys show that the process of changing the lifestyle produces a new form of social tastes among the mass of people and even the elite part of the societies. As a result, with the emergence of new political demands and the politicians who believe in the emerging models, the political system, by revising its previous process, steps on the path of changing the political regime.