One of the planned actions of the enemies of the Islamic Revolution is the cultural influence that they have used in recent years against the Islamic Republic of Iran. Given the importance of this issue, from the perspective of the Supreme Leader, the present study, using a descriptive-analytical method, seeks to explain the nature of cultural influence and descriptive strategies to oppose it. According to the guidelines of the Supreme Leader, after explaining the nature of cultural influence, the author examines the dimensions of influence including three areas: economic, political and cultural, and after stating the methods and tools of cultural influence, examines its solutions in two pivots. In the first pivot, cultural strategies in the field of epistemology-cognition are stated, which include: accepting cultural influence, promoting religious beliefs and understanding Islamic culture, and in the second pivot, cultural strategies in the field of behavior including: cultural management, organizational activity and having the initiative in cultural affairs are examined.