In the last century, great thinkers can be found who endured many hardships and difficulties to achieve the ideal of forming a single nation and Islamic civilization. The question of this research is what are the pillars of the formation of a single Islamic nation from the point of view of Imam Khomeini + and the Supreme Leader as the two leaders of the most important and greatest revolution, which also has the suffix "Islamic"? To answer this question, we went to the works and writings of the Imam and the leadership and analyzed their thoughts with a theoretical framework derived from the works of the Imam. Religion, rationality, science and ethics from the perspective of the Imam and the Supreme Leader are the four pillars of the formation of a single nation and Islamic civilization.