Middle-east region has been at the center of attention since a long time ago due to its special geopolitical situation as well as its bountiful energy resources. Domination system's attention to this region is because they try to secure their future energy and guarantee Israel's security against Islamic countries subsequent to Islamic awakening. Therefore natural resources in this region can be a powerful tool at the disposal of transformed Islamic countries in the middle-east which they can apply to implement their objectives for the future and not be defeated and passive in the interaction with domination system. They should try to change the same natural resources which were threats for them into opportunities for progress. This article tries to review supreme leader's statements about preservation of natural resources by Islamic countries and western conspiracies to re-dominate the region after new Islamic governments are in place. It also emphasizes the importance of natural resources to put more pressure on domination system and west and proposes some solutions.