In this article, an attempt has been made to explain the necessity for creating an approach to Islamic social science from the perspective of the international meaningfulness arising from the Islamic Revolution, and based on the reconstruction of Morteza Motahari's conception of the relationship between the two. Epistemologically and culturally, the Islamic Revolution should be considered as a turning point that put Iranian society on a different historical path. This fact causes the Islamic Revolution not to use modern social science in order to understand and design society. The main question is what in Motahari's thought is the necessity of Islamic social science from the perspective of the international meaningfulness arising from the Islamic Revolution? To solve this problem, Motahhari's writings have been studied by the method of qualitative content analysis. Finally, we came to the conclusion that why the production of Islamic social science goes back to three things: "achieving the quorum of Islamic monotheism", "protecting the independence of our epistemological and social world", and "the inability of secular social science to understand our social realities.