USA and Afghanistan`s Treaty of Strategic Partnership was signified to establish security, stability and improve political, social and cultural conditions in Afghanistan. Regarding hostile relations of USA and IRI, the treaty would bear some threats against IRI`s national security. However, main question in the field consists in: what threats would this strategic treaty being followed by a long time presence of USA in Afghanistan and IRI`s boundaries bear against IRI`s national security? The study, using analytical descriptive and library-based method, has founded that the treaty would be of threats in different political, military-security, economic and social levels.