The question of the present study intended to answer with a descriptive-analytical approach is: How may the effects of Islamophobia on the cultural relations between the IRI and the West during the post-Islamic Revolution era be assessed? The hypothesis of the study is that the phenomenon of Islamophobia in the cultural dimension during the recent years and even decades in a creeping and slow progress has left its limited and informal form and embodied purposefully within a formal and legal frameworks at three levels: 1) at the government level in the form of decisions made in the think tank; 2) The level of public space of society in the form of verbal and physical violence as well as in the form of discrimination in civil rights; And 3) Media level in the form of negative image-making.