Undoubtedly, the Islamic Revolution of Iran is one of the most influential developments in recent decades in the Middle East, and the spirit and thought of this revolution has been significantly influential in many regional developments. Naturally, the United States, as a hegemonic power, sees Iran as a staunch rival in the Middle East and is always trying to steer the movements in the Middle East known as the Islamic Awakening. This article seeks to examine the opportunities and challenges that arise in this regard for the diplomatic apparatus of the Islamic Republic. The main finding of this paper indicates that active Iranian diplomacy can make the most of these opportunities and contain the threats and turn them into exceptional opportunities.