The discourse of the Islamic Revolution, with an emphasis on new signs, drew a new outlook to contemporary people who were disillusioned of current discourses, and analyzed human being and international relations from a new angle. The question of this article follows as: does the discourse of the Islamic Revolution affected the societies lacking cultural and social commonality with Iran such as South America? Relying on the writings, interviews and published news, one will find that there is a wide variety of evidence on the impact of Islamic Revolution discourse at various levels in the South American region. Venezuela was studied as a country affected by this discourse. The findings suggest that the Islamic Revolution, with its new articulation of concepts and signs, has changed the political, economic, and cultural alignments in the region by opening up a new approach to human life that has resulted in state of self-esteem, self-belief, and being in opposition to tyranny.