In addition to its geographic prominence, the Middle East region possesses an important position in foreign policy of great powers especially the United States. Through the implementation of different policies, these powers seek to secure their interests and interpret historical events into their own interests. Muslim nations' uprising is one of the most important developments in the Middle East region in recent years and has exerted numerous impacts on the region, the world and policies of ultra-national powers. The main inquiry of this article in this regard is, in view of the position of the Middle East in foreign policy of great powers especially the United States, what impacts Islamic awakening has had on political order in the Middle East and the status of the United States in this region.