The Islamic Revolution, as the greatest historical evolution of contemporary times, has caused America`s interests face many challenges. Understanding the tools and strategies used by the United States against the Islamic Republic of Iran helps us to better understand and confront the country. In this regard, using the theory of invasive realism, American strategies against the Islamic Republic have been dealt with. In fact, the main question of the research is that: how has the American strategies been used to curb the Islamic Republic over the past four decades? To answer this question, the theory of aggressive realism has been used to analyze the proposed strategies based on Mearsheimer's view as the main theorist of aggressive realism. As explained in the paper, we can refer to US utilization of the strategies of handing the liability to its regional followers, balancing, warfare, enticing and bullying, in order to control the power and influence of the Islamic Republic of Iran.