The prediction of the destruction of Israel made by the Supreme Leader, like any other prediction, is based on a set of epistemological, ontological, anthropological, theological and value foundations. The present study seeks to answer the main question: what theoretical basis is the prediction of the destruction of Israel by the Supreme Leader based? The present study, in the first step, deals with the semantics of prediction and its importance and challenges. And it has considered the common value and nature of human beings and in the end, it has enumerated the Qur'anic evidences of the correctness of the obtained results.